2-Chloro acetophenone
2-Chloroacetophenone
CAS: 532-27-4
Molecular Formula: C8H7ClO
2-Chloro acetophenone - Names and Identifiers
| Name | 2-Chloroacetophenone |
| Synonyms | phenacyl nci-c55107[qr] 2-Chloroacetophenone phenacylchloride[qr] α-chloroacetophenone 2-Chloro acetophenone phenylchloromethylketone Phenyl chloromethyl ketone -Phenyl-2-chloro-1-ethanone omega-chloroacetophenone[qr] phenacylchloride(2-chloroacetophenone) |
| CAS | 532-27-4 |
| EINECS | 208-531-1 |
| InChI | InChI=1/C8H7ClO/c9-6-8(10)7-4-2-1-3-5-7/h1-5H,6H2 |
| InChIKey | IMACFCSSMIZSPP-UHFFFAOYSA-N |
2-Chloro acetophenone - Physico-chemical Properties
| Molecular Formula | C8H7ClO |
| Molar Mass | 154.59 |
| Density | 1.188 |
| Melting Point | 52-56℃ |
| Boling Point | 244-245℃ |
| Flash Point | 118℃ |
| Water Solubility | insoluble. <0.1 g/100 mL at 19℃ |
| Vapor Presure | 4 at 20 °C, 14 at 30 °C (quoted, Verschueren, 1983) |
| Appearance | Morphological Colorless crystals |
| Stability | May decompose upon exposure to air or water. Incompatible with bases, amines, alcohols. |
| Refractive Index | 1.5438 |
| Physical and Chemical Properties | Density 1.188 melting point 52-56°C boiling point 244-245°C flash point 118°C refractive index 1.5438 water-soluble insoluble. <0.1g/100 mL at 19°C |
| Use | Used as pharmaceutical intermediates for pharmaceutical and for organic synthesis |
2-Chloro acetophenone - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R23/25 - Toxic by inhalation and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 1697 |
| WGK Germany | 3 |
| RTECS | AM6300000 |
| FLUKA BRAND F CODES | 9-19 |
| TSCA | Yes |
| Hazard Class | 6.1 |
| Packing Group | II |
| Toxicity | LD50 in rats (mg/kg): 41 i.v., 36 i.p., 127 orally; LC50 in rats: 8750 mg/min/m3 (Ballantyne, Swanston) |
2-Chloro acetophenone - Upstream Downstream Industry
2-Chloro acetophenone - Nature
Open Data Verified Data
white or pale yellow crystals with a relative density of 1. 324. Melting point 54 C (56.5 C). Boiling point 244~245 ℃,139~141 ℃(1. 86kPa). Insoluble in water, soluble in ether, ethanol, chloroform, benzene, etc. Steam distillation can be performed.
Last Update：2024-01-02 23:10:35
2-Chloro acetophenone - Preparation Method
Open Data Verified Data
There are two ways.
- acetophenone chloride method acetophenone is pumped into the reaction kettle, chlorine gas is introduced, and the reaction is carried out at 60~80 ℃ until the chlorine gas reaches the theoretical amount, and the low boiling substance is distilled off under reduced pressure, the mixture was cooled to below 5 ° C., allowed to stand, crystals were precipitated, and the product was obtained by filtration.
- Chloroacetyl Chloride method dichlorosulfoxide is added to chloroacetic acid, stirring reflux, distilling out the crude product, mixing it with carbon disulfide, slowly adding to the mixture of benzene, anhydrous aluminum trichloride and carbon disulfide, keep the temperature below 30 ℃, refluxing with heat after adding, let stand, pour into ice water and dilute hydrochloric acid solution, filter and blow dry, crystallize with dilute ethanol, and obtain the product by distillation under reduced pressure.
Last Update：2022-01-01 10:42:41
2-Chloro acetophenone - Use
Open Data Verified Data
This product is used in organic synthesis, in medicine for the synthesis of hydrochloric acid four imidazole and so on.
Last Update：2022-01-01 10:42:41
2-Chloro acetophenone - Safety
Open Data Verified Data
by high heat points to explain the release of toxic gases. Toxic and corrosive gases are released from contact with water or steam. Highly corrosive articles. Toxic. It's a tear-inducing military agent. Rat oral LD50:50mg/kg. Strong irritation and corrosive to the eyes, skin and mucous membranes.
Last Update：2022-01-01 10:42:42
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CAS: 532-27-4
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View History
2-Chloro acetophenone
双(2,4,6-三氯苯基)草酸酯[用于荧光性化合物测定的化学发光试剂]
Ammonium nitrite [Forbidden]
(5-氟-2-甲氧基嘧啶-4-基)肼
依来曲普坦中间体5
3-(苄氨基)氧杂环丁烷-3-羧酸
Glycerol 1-monooleate
二钠(乙二胺四乙酸基)镁酸盐四水合物
2-噻吩基锂
WS-5
双(2,4,6-三氯苯基)草酸酯[用于荧光性化合物测定的化学发光试剂]
Ammonium nitrite [Forbidden]
(5-氟-2-甲氧基嘧啶-4-基)肼
依来曲普坦中间体5
3-(苄氨基)氧杂环丁烷-3-羧酸
Glycerol 1-monooleate
二钠(乙二胺四乙酸基)镁酸盐四水合物
2-噻吩基锂
WS-5
Raw Materials for 2-Chloro acetophenone
Downstream Products for 2-Chloro acetophenone
Tetrachlorvinphos
DL-Mandelic acid
(R)-Styrene oxide
Phenethyl chloride
diethyl 2-acetamido-2-phenethyl-propanedioate
PHENACYL THIOCYANATE
DL-Mandelic acid
(R)-Styrene oxide
Phenethyl chloride
diethyl 2-acetamido-2-phenethyl-propanedioate
PHENACYL THIOCYANATE